French Champions, PSG humbled Manchester United at Trafford with a 2-0 win.
The Perisiens went into the game with a depleted squad, missing Neymar and Cavani to injury.
Nevertheless, they managed to beat Manchester United 2-0, the first defeat under the guidance of caretaker coach Solskjaer.
Both goals in the game came in the 2nd half via a Di Maria assist.
Defender Kimpembe scored the first, connecting a Di Maria corner kick pass De Gea.
Mbappe added the 2nd in the 60th minute.
The game was nearly marred by a card hungry referee Orsato with 9 yellow cards and a red for Pogba.
In the other Round 16 game, AS Roma defeated FC Porto 2-1.
19 year old Nicola Zaniolo scored the two goals for Roma and Adrian Lopez got the consolation for Porto.
The return leg will be played in three weeks time.